Computational and Mathematical Methods in Medicine / 2016 / Article / Tab 2

Research Article

In Silico Evaluation of the Potential Antiarrhythmic Effect of Epigallocatechin-3-Gallate on Cardiac Channelopathies

Table 2

Formulation of WT and mutated sodium channels (-p.R222Q and -p.I141V) in the presence or absence of 30 µM of E3G in the Maleckar-Greenstein-Trayanova-Giles atrial cell model. The bold font corresponds to mutations effect and the bold-italic font to E3G effects.

MGTG atrial model, p.R222Q.MGTG atrial model, p.I141V.⁢MGTG atrial model, ⁢MGTG atrial model,

WT, WT () = , WT (), WT () = , WT ()100% of 100% of
factor, WT () = factor, WT ()
factor, WT () = factor, WT ()
, WT () = , WT (), WT () = , WT ()
factor, WT () = factor, WT () factor, WT () = factor, WT ()
= 0.03 (s) + 0.0003 (s) = 0.03 (s) + 0.0003 (s)

WT + 30 µM E3G, WT () = , WT (), WT () = , WT ()80% of 50% of
factor, WT () = factor,
WT ()
factor, WT () = factor, WT ()
, WT () = , WT ( + 6), WT () = , WT ( + 6)
factor, WT () = factor, WT () factor, WT () = factor, WT ()
= 0.03 (s) + 0.0003 (s) = 0.03 (s) + 0.0003 (s)

Mutants, WT () = m, WT ( + 6.3), WT () = , WT ( + 7)100% of 100% of
factor, WT () = factor, WT () factor, WT () = factor, WT ( + 7)
, WT () = , WT ( + 6.2), WT () = , WT ()
factor, WT () = factor, WT () factor, WT () = factor, WT ( + 7)
= 0.03 (s) + 0.0003 (s) = 0.03 (s) + 0.0003 (s)

Mutants + 30 µM E3G, WT () = , WT ( + 6.3), WT () = , WT ( + 7)80% of 50% of
factor, WT () = factor, WT () factor, WT () = factor, WT ( + 7)
, WT () = , WT ( + 6.2 + 6), WT () = , WT ( + 6)
factor, WT () = factor, WT () factor, WT () = factor, WT ( + 7)
= 0.03 (s) + 0.0003 (s) = 0.03 (s) + 0.0003 (s)

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