In Silico Evaluation of the Potential Antiarrhythmic Effect of Epigallocatechin-3-Gallate on Cardiac Channelopathies

Table 2

Formulation of WT and mutated sodium channels (-p.R222Q and -p.I141V) in the presence or absence of 30 µM of E3G in the Maleckar-Greenstein-Trayanova-Giles atrial cell model. The bold font corresponds to mutations effect and the bold-italic font to E3G effects.

	MGTG atrial model, p.R222Q.	MGTG atrial model, p.I141V.	⁢MGTG atrial model,	⁢MGTG atrial model,
⁢WT	, WT () = , WT ()	, WT () = , WT ()	100% of	100% of
	factor, WT () = factor, WT ()	factor, WT () = factor, WT ()
	, WT () = , WT ()	, WT () = , WT ()
	factor, WT () = factor, WT ()	factor, WT () = factor, WT ()
	= 0.03 (s) + 0.0003 (s)	= 0.03 (s) + 0.0003 (s)
WT + 30 µM E3G	, WT () = , WT ()	, WT () = , WT ()	80% of	50% of
	factor, WT () = factor,; WT ()	factor, WT () = factor, WT ()
	, WT () = , WT ( + 6)	, WT () = , WT ( + 6)
	factor, WT () = factor, WT ()	factor, WT () = factor, WT ()
	= 0.03 (s) + 0.0003 (s)	= 0.03 (s) + 0.0003 (s)
	Mutants	, WT () = m∞, WT ( + 6.3)			, WT () = , WT ( + 7)	100% of	100% of
factor, WT () = factor, WT ()		factor, WT () = factor, WT ( + 7)
, WT () = , WT ( + 6.2)		, WT () = , WT ()
factor, WT () = factor, WT ()		factor, WT () = factor, WT ( + 7)
= 0.03 (s) + 0.0003 (s)		= 0.03 (s) + 0.0003 (s)
Mutants + 30 µM E3G		, WT () = , WT ( + 6.3)	, WT () = , WT ( + 7)	80% of	50% of
	factor, WT () = factor, WT ()	factor, WT () = factor, WT ( + 7)
	, WT () = , WT ( + 6.2 + 6)	, WT () = , WT ( + 6)
	factor, WT () = factor, WT ()	factor, WT () = factor, WT ( + 7)
	= 0.03 (s) + 0.0003 (s)	= 0.03 (s) + 0.0003 (s)