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Computational and Mathematical Methods in Medicine
Volume 2017, Article ID 1403940, 12 pages
Research Article

Altered Brain Functional Connectivity in Small-Cell Lung Cancer Patients after Chemotherapy Treatment: A Resting-State fMRI Study

1School of Electrical and Computer Engineering, National Technical University of Athens, Athens, Greece
2Hellenic Military University, Vari, Athens, Greece
3Research Centre of Radiology and Imaging, “Evgenidion” General Hospital, Athens, Greece
42nd Department of Radiology, Radiotherapy Unit, ATTIKON University Hospital, Athens, Greece

Correspondence should be addressed to Konstantinos Bromis; moc.liamg@shmorpmk and Vasileios Kouloulias; rg.autn.ece@luoluokv

Received 5 February 2017; Revised 6 May 2017; Accepted 15 June 2017; Published 17 July 2017

Academic Editor: Yuhai Zhao

Copyright © 2017 Konstantinos Bromis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Previous studies in small-cell lung cancer (SCLC) patients have mainly focused on exploring neurocognitive deficits associated with prophylactic cranial irradiation (PCI). Little is known about functional brain alterations that might occur due to chemotherapy treatment in this population before PCI is administered. For this reason, we used resting-state functional Magnetic Resonance Imaging (fMRI) to examine potential functional connectivity disruptions in brain networks, including the Default Mode Network (DMN), the Sensorimotor Network, and the Task-Positive Network (TPN). Nineteen SCLC patients after platinum-based chemotherapy treatment and thirteen controls were recruited in the current study. ROI-to-ROI and Seed-to-Voxel analyses were carried out and revealed functional connectivity deficits in patients within all the networks investigated demonstrating the possible negative effect of chemotherapy in cognitive functions in SCLC populations.