Altered Brain Functional Connectivity in Small-Cell Lung Cancer Patients after Chemotherapy Treatment: A Resting-State fMRI Study

Table 2

ROI-to-ROI analysis. Statistically significant lower functional connectivity in patient group compared to controls.

Network	Seed regions	Target regions	Coordinates		-unc	-FDR
Default Mode Network	Posterior cingulate cortex, bilateral	Superior frontal gyrus, left	(−4, 53, 33)	4.8	0.0001	0.0014
		Paracingulate gyrus, bilateral (BA32)	(−2, 42, −5)	4.15	0.0003	0.0028
		Frontal pole, left	(−13, 59, 20)	4.14	0.0003	0.0028
		Frontal pole, right	(−4, 60, 2)	3.36	0.0021	0.0176
		Cingulum, bilateral	(2, −16, 36)	3.33	0.0023	0.0255
		Superior frontal gyrus, right	(18, 38, 47)	2.97	0.0058	0.0319
		Superior frontal gyrus, bilateral	(1, 56, 19)	2.83	0.0082	0.0388
		Paracingulate gyrus, bilateral (BA9)	(−4, 47, 17)	2.77	0.0096	0.0394
		Paracingulate gyrus, bilateral (BA24)	(−2, 42, −10)	2.63	0.0133	0.0489
Task-Positive Network	Anterior intraparietal sulcus, bilateral	Middle frontal gyrus, left	(−40, 35, 29)	4.66	0.0001	0.0024
		Visual cortex-V5, left	(−49, −66, −6)	4.6	0.0001	0.0028
		AIPS, left (BA7)	(−44, −36, 45)	3.14	0.0037	0.0468
		Superior parietal lobule, left	(−26, −56, 57)	2.98	0.0056	0.0468
		Premotor cortex, left	(−28, −2, 53)	2.96	0.006	0.0468
Somatosensory Network	Primary somatosensory cortex, bilateral	Premotor cortex, right	(23, −21, 71)	3.58	0.0012	0.0132
		Premotor cortex, left	(−36, −22, 64)	2.89	0.0071	0.0392
		Primary motor cortex, right	(37, −22, 58)	2.62	0.0135	0.0497

mm: Talairach space. Anterior intraparietal sulcus. Difference corresponds to the correlation between the two seed regions.