Research Article
A Multiscale Model for the World’s First Parasitic Disease Targeted for Eradication: Guinea Worm Disease
Table 3
Sensitivity indices of model reproduction number
to parameters for model system (
1), evaluated at the parameters values presented in Tables
4–
6.
| Parameter | Description | Sensitivity index with positive sign | Sensitivity index with negative sign |
| | Natural decay rate of copepods in the water environment | | −0.9991 | | Natural decay rate of copepods within human host | | −0.4853 | | Release rate of mature worms within human host | | −0.4853 | | Human birth rate | +0.50013 | | | Human infection rate | +0.5 | | | Fecundity rate of worm larvae in the environment | +0.5 | | | Natural decay rate of Guinea worm larvae | | −0.5 | | Larvae saturation constant | | −0.5 | | Fecundity rate of mature worm | +0.5 | | | Copepods birth rate | +0.5 | | | Copepods infection rate | +0.5 | | | Copepods saturated constant | | −0.5 | | Human recovery | | −0.4998 | | Natural decay rate of fertilized female worms | | −0.4639 | | Migration rate of fertilized female worms to surface of host’s skin | +0.4639 | | | Natural decay rate of worm eggs in the water environment | | −0.4545 | | Worm egg hatching rate | +0.4545 | | | Natural decay rate of mature worms within human host | | −0.25 | | Migration rate of mature worms to subcutaneous tissues | +0.25 | | | Dilution/degradation rate of gastric juice | | −0.0147 | | Supply rate of gastric juice from the source of the body | +0.0147 | | | Induced decay rate of copepods in the water environment | | −0.000894 |
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