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Computational and Mathematical Methods in Medicine
Volume 2017, Article ID 2414878, 12 pages
Research Article

Mathematical Simulation of Transport Kinetics of Tumor-Imaging Radiopharmaceutical 99mTc-MIBI

1Institute for Safety Problems of NPP, The National Academy of Sciences of Ukraine, Lisogirskaya Str. 12, Kyiv, Ukraine
2National Medical University of O.O. Bogomolets, Pr. Peremogi 34, Kyiv, Ukraine

Correspondence should be addressed to O. N. Shevtsova; moc.liamg@avostvehsko

Received 18 March 2017; Accepted 9 May 2017; Published 15 June 2017

Academic Editor: Kazuhisa Nishizawa

Copyright © 2017 O. N. Shevtsova and V. K. Shevtsova. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The proposed model describes in a quality way the process of tumor-imaging radiopharmaceutical -MIBI distribution with taking into account radiopharmaceutical accumulation, elimination, and radioactive decay. The dependencies of concentration versus the time are analyzed. The model can be easily tested by the concentration data of the radioactive pharmaceuticals in the blood measured at early time point and late time point of the scanning, and the obtained data can be used for determination of the washout rate coefficient which is one of the existing oncology diagnostics methods.