Research Article
Dynamics of Immune Checkpoints, Immune System, and BCG in the Treatment of Superficial Bladder Cancer
Table 1
List of all parameters used in numerical simulations.
| | Parameter | Interpretation
(units) | Estimated value | Reference |
| | Tumor growth rate
= day−1 | | Shochat et al., 1999 | | Rate of elimination of cancer cells by effector cells
cell day−1 | | Kuznetsov et al., 1994 | | Inhibitory parameter | | Not found | | Recruitment rate of effector cells
= day−1 | | Sud D. et al., 2006 | | Activation rate of effector cells by the BCG
cells−1 day−1 | | Wigginton and Kirschner, 2001 | | Internal production of immune checkpoints | | Sandip Banerjee et al., 2015 | | Elimination rate of effector cells by cancer cells
cells−1 day−1 | | Kuznetsov et al., 1994 | | Degradation rate of effector cells
= day−1 | | Kuznetsov et al., 1994 | | Rate of BCG decay
= day−1 | | Archuleta et al., 2002 | | Bioeffective concentration of BCG
c.f.u./day | | Cheng et al., 2004 | | Destruction of BCG by effector cells
cells−1 day−1 | | Wigginton and Kirschner, 2001 | | Degradation rate of immune checkpoints
= day−1 | | Sandip Banerjee et al., 2015 |
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