Research Article
Computational Insight into Protein Tyrosine Phosphatase 1B Inhibition: A Case Study of the Combined Ligand- and Structure-Based Approach
Table 2
Summary of the pharmacophore models generated by HipHop for PTP1B inhibitors.
| Hypothesis | Features | Rank | Direct hit | Partial hit | Max. fit |
| 01 | RNHHA | 96.526 | 10111111 | 01000000 | 5 | 02 | RHHAA | 88.605 | 10111111 | 01000000 | 5 | 03 | RNHHA | 88.290 | 10111111 | 01000000 | 5 | 04 | RRNAA | 86.770 | 10111111 | 01000000 | 5 | 05 | RNHA | 85.881 | 11111111 | 00000000 | 4 | 06 | RHHAA | 85.819 | 10111111 | 01000000 | 5 | 07 | RRHAA | 85.193 | 10111111 | 01000000 | 5 | 08 | RNHA | 84.838 | 11111111 | 00000000 | 4 | 09 | HHHAA | 84.535 | 10111111 | 01000000 | 5 | 10 | RHHAA | 84.392 | 10111111 | 01000000 | 5 | 11 | RNHA | 83.968 | 11111111 | 00000000 | 4 | 12 | RHHAA | 83.877 | 10111111 | 01000000 | 5 | 13 | RNHA | 83.439 | 11111111 | 00000000 | 4 | 14 | HHHAA | 83.363 | 10111111 | 01000000 | 5 | 15 | RHHAA | 82.987 | 10111111 | 01000000 | 5 |
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