Table of Contents Author Guidelines Submit a Manuscript
Computational and Mathematical Methods in Medicine
Volume 2017 (2017), Article ID 4797051, 21 pages
Research Article

The Preventive Control of Zoonotic Visceral Leishmaniasis: Efficacy and Economic Evaluation

1Faculty of Medicine, University of São Paulo and LIM 01-HCFMUSP, Avenida Dr. Arnaldo 455, 01246-903 São Paulo, SP, Brazil
2Centre for Disease Modelling, York Institute for Health Research, York University, 4700 Keele Street, Toronto, ON, Canada M3J 1P3
3London School of Hygiene and Tropical Medicine, University of London, London, UK

Correspondence should be addressed to Helio Junji Shimozako

Received 4 January 2017; Revised 23 March 2017; Accepted 28 March 2017; Published 15 May 2017

Academic Editor: Chung-Min Liao

Copyright © 2017 Helio Junji Shimozako et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Zoonotic Visceral Leishmaniasis (ZVL) is one of the world’s deadliest and neglected infectious diseases, according to World Health Organization. This disease is one of major human and veterinary medical significance. The sandfly and the reservoir in urban areas remain among the major challenges for the control activities. In this paper, we evaluated five control strategies (positive dog elimination, insecticide impregnated dog collar, dog vaccination, dog treatment, and sandfly population control), considering disease control results and cost-effectiveness. We elaborated a mathematical model based on a set of differential equations in which three populations were represented (human, dog, and sandfly). Humans and dogs were divided into susceptible, latent, clinically ill, and recovery categories. Sandflies were divided into noninfected, infected, and infective. As the main conclusions, the insecticide impregnated dog collar was the strategy that presented the best combination between disease control and cost-effectiveness. But, depending on the population target, the control results and cost-effectiveness of each strategy may differ. More and detailed studies are needed, specially one which optimizes the control considering more than one strategy in activity.