Computational and Mathematical Methods in Medicine / 2017 / Article / Tab 1

Research Article

Estimating and Interpreting Effects from Nonlinear Exposure-Response Curves in Occupational Cohorts Using Truncated Power Basis Expansions and Penalized Splines

Table 1

Estimated hazard ratios (HR) and 95% pointwise confidence intervals from two Cox proportional hazard model fits.

Exposure
value
Penalized spline function AICc as in Figure 6Linear spline function with knots at quartiles of case
exposures as in Figure 5(a)
True HR

2.01.3 (1.2, 1.5)1.3 (1.1, 1.6)1.5
3.01.5 (1.3, 1.8)1.5 (1.1, 2.1)1.7
4.01.8 (1.4, 2.2)1.8 (1.3, 2.3)2.0
5.02.0 (1.6, 2.5)2.1 (1.6, 2.7)2.3
7.02.5 (2.0, 3.1)2.5 (2.0, 3.3)2.9
9.02.9 (2.3, 3.6)2.9 (2.2, 3.8)3.5
19.33.7 (2.1, 6.3)4.1 (2.5, 6.5)4.0
21.13.5 (1.7, 7.3)4.3 (2.5, 7.5)3.5
24.03.3 (1.1, 9.9)4.7 (2.4, 9.2)2.6

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