Evaluation of Treatment Effect with Paired Failure Times in a Single-Arm Phase II Trial in Oncology

Table 1

Estimation of for the four situations in the FFCD 2000-05 trial.

	Treatment			Events	Estimator
	Line 1	Line 2			Parametric	Nonparametric
Arm C
Situation 1	FOLFOX	FOLFIRI	129	114	0.21 [0.14; 0.29]	0.24 [0.17; 0.31]
Situation 3	FOLFIRI	Investigator	74	59	0.52 [0.41; 0.63]	0.54 [0.43; 0.65]
Arm S
Situation 2	LV5FU2	FOLFOX	152	122	0.54 [0.46; 0.62]	0.48 [0.40; 0.56]
Situation 4	FOLFOX	FOLFIRI	92	79	0.24 [0.15; 0.33]	0.27 [0.18; 0.36]