Table 3: Input vector selected for GP modeling.

Orig input numberEquation (2) labelLabelDescription

(1)-CYP1A2Liver CYP1A2 abundance [pmol/mg of protein]
(11)-CYP3A4Liver CYP3A4 abundance [pmol/mg of protein]
(14)-Gut_CYP2C9Gut CYP2C9 abundance [pmol/mg of protein]
(20)-Sex_CodePatients’ gender [male/female]
(22)-WeightPatients’ weight [kg]
(24)BSAPatients’ body surface area [m2]
(29)-Cardiac_OutputPatient’s cardiac output [L/h]
(41)KPatients’ plasma potassium concentration [mM]
(42)NaPatients’ plasma sodium concentration [mM]
(43)Ca2Patients’ plasma calcium concentration [mM]
(44)IKr_inhibitionPatients’ and drugs’ specific IKr current inhibition [0–100%]
(45)IKs_inhibitionPatients’ and drugs’ specific IKs current inhibition [0–100%]
(46)INa_inhibitionPatients’ and drugs’ specific INa current inhibition [0–100%]
(47)ICa_inhibitionPatients’ and drugs’ specific ICa current inhibition [0–100%]
(49)dQTcdQTcOutput (QTc interval modification as compared to baseline)