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Computational and Mathematical Methods in Medicine
Volume 2018, Article ID 3829768, 13 pages
https://doi.org/10.1155/2018/3829768
Research Article

Direct-Current Electric Field Distribution in the Brain for Tumor Treating Field Applications: A Simulation Study

Department of Physics, Fu-Jen Catholic University, New Taipei City 24205, Taiwan

Correspondence should be addressed to Yung-Shin Sun; wt.ude.ujf.liam@759980

Received 25 October 2017; Revised 25 December 2017; Accepted 30 January 2018; Published 22 February 2018

Academic Editor: Marta Parazzini

Copyright © 2018 Yung-Shin Sun. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Tumor Treating Fields (TTFields) in combination with chemotherapy and/or radiotherapy have been clinically reported to provide prolonged overall survival in glioblastoma patients. Alternating electric fields with frequencies of 100~300 kHz and magnitudes of 1~3 V/cm are shown to suppress the growth of cancer cells via interactions with polar molecules within dividing cells. Since it is difficult to directly measure the electric fields inside the brain, simulation models of the human head provide a useful tool for predicting the electric field distribution. In the present study, a three-dimensional finite element head model consisting of the scalp, the skull, the dura, the cerebrospinal fluid, and the brain was built to study the electric field distribution under various applied potentials and electrode configurations. For simplicity, a direct-current electric field was used in the simulation. The total power dissipation and temperature elevation due to Joule heating in different head tissues were also evaluated. Based on the results, some guidelines are obtained in designing the electrode configuration for personalized glioblastoma electrotherapy.