Explicit Theoretical Analysis of How the Rate of Exocytosis Depends on Local Control by Ca²⁺ Channels

Figure 2

Expected exocytosis rate for single granule coupled with one (inactivating or non-inactivating) CaV. (a, b) Expected exocytosis rate for the granule at different distances from one inactivating (a) or non-inactivating (b) CaV: nm (blue curves),  nm (red),  nm (green), and  nm (magenta). Note the different scales on the y-axes. The insert in (b) is a zoom on the lower, left part of the figure for comparison with (a). (c, d) Relative rate computed at different distances ( nm (red),  nm (green), and  nm (magenta)) of the granule from the inactivating (c) or not-inactivating (d) CaV and compared to the case with  nm.

(a)

(b)

(c)

(d)