Computational and Mathematical Methods in Medicine

Research Article

Evaluation of the Feasibility of Screening Tau Radiotracers Using an Amyloid Biomathematical Screening Methodology

Table 2

Comparison of predicted and clinically observed K₁, k₂, and BP_ND values of four clinically applied tau radiotracers.


Radiotracers	Literature				Predicted values	% diff
Radiotracers	Parameters	Region	Clinically observed values	References	Predicted values	% diff

[¹⁸F]flortaucipir	K₁	Cerebellum excluding vermis	0.26	[36]	0.256	−1.54
[¹⁸F]flortaucipir	k₂		0.17	[36]	0.199	17.1
[¹⁸F]THK5351 (S-enantiomer of [¹⁸F]THK5151)	k₂^′^‡	Target^β	0.115	[38]	0.140	21.7
[¹⁸F]THK5317 (S-enantiomer of [¹⁸F]THK5117)	K₁	Target^δ	0.33	[35]	0.202	−38.8
	k₂		0.09	[35]	0.087	−3.33
	BP_ND (AD)	Putamen	0.60	[39]	0.125	−79.2
[¹¹C]PBB3	BP_ND (AD)^¶	High-binding cortical regions	0.37	[10]	0.427	15.4
[¹⁸F]MK6240	K₁	Posterior cingulate cortex	0.246	[16]	0.252	2.50
	k₂		0.099		0.138	39.2
	BP_ND^§		5.11		8.13	59.2

^βTarget ROIs: anterior cingulate, brainstem, caudate nucleus, eroded white matter, entorhinal cortex, frontal cortex, fusiform gyrus, hippocampus, inferior temporal cortex, lingual gyrus, middle temporal gyrus, occipital cortex, pallidum, parahippocampal gyrus, parietal cortex, posterior cingulate, precuneus, putamen, thalamus. ^δTarget ROIs: thalamus, putamen, hippocampus, amygdala, parietal cortex, frontal cortex, sensory motor cortex, occipital cortex, midbrain, entorhinal cortex, and temporal cortex. BP_ND = DVR-1, where DVR was determined using reference Logan, averaged from 4 prodromal AD. ^¶BP_ND determined using MRTM₀. ^§BP_ND determined using k₃/k₄ using 2T4CM in 7 symptomatic individuals classified as MCI and AD. ^‡k₂^′ optimized from fitting all target ROIs using SRTM with cerebellum as the reference region.