Euclidean Distance Analysis Enables Nucleotide Skew Analysis in Viral Genomes

Table 1

Mean skew values of coronavirus, flavivirus, picornavirus, and HIV-1 subtype RNA genomes. HIV-1 subtype RNAs display much lower StDEV of skew values compared with those of the other viruses.

Skew values		C vs G	G vs A	U vs G	U vs A	C vs A	U vs C
Coronavirus	AVG	−29.09	−58.05	101.36	40.51	−86.34	124.36
	StDev	46.67	33.47	21.40	24.00	43.15	45.22
Flavivirus	AVG	−43.38	38.95	−44.53	−5.01	−3.66	−1.19
	StDev	29.92	53.33	32.36	59.98	71.05	25.50
Picornavirus	AVG	9.48	−32.05	37.12	2.81	−24.10	26.49
	StDeV	62.05	45.85	40.06	39.51	95.34	81.95
HIV	AVG	−77.15	−101.30	−17.95	−118.86	−171.62	59.48
	StDEV	3.82	7.00	3.46	6.20	7.32	5.26