Developing a Minimally Structured Mathematical Model of Cancer Treatment with Oncolytic Viruses and Dendritic Cell Injections

Figure 1

An example illustrating the ellipsoidal nature of the cost function near the best-fit parameters for Equation (10). Note that parameters on each axis are scaled by the optimal value, indicated with . Only parameters where the cost is less than 0.1 (deviation from optimal value of is 10% or less) are shown. (a) Also shows the contours of the best-fit quadratic surface to this data. (b) Also shows the eigenvectors of the associated Hessian matrix. The near-vertical eigenvector (which appears less vertical than it actually is due to axes scaling) has with , and the near-horizontal eigenvector has with .

(a)

(b)