Likelihood-Ratio-Test Methods for Drug Safety Signal Detection from Multiple Clinical Datasets

Table 3

Results of PPIs data (for PLandPPI vs. PL). obsstat is the statistics shown in Table 1 for different methods, obtained from the observed data.

	1st occurrence of AEOST			Repeated occurrences of AEOST
	obsstat	value	95% threshold	obsstat	value	95% threshold
Individual study analysis using regular LRT
s = 1	0.12	0.99	1.79	0.93	0.438	1.96
s = 2	4.16	0.004	2.10	24.28	0	2.00
s = 3	0.56	0.61	1.73	1.18	0.243	1.18
s = 4	1.83	0.07	2.04	4.63	0.006	2.03
s = 5	1.54	0.137	1.69	4.88	0.006	2.27
s = 6	2.43	0.031	0.97	3.97	0.009	1.17
Simple pooled analysis using regular LRT
	6.12	0.003	1.78	34.27	0.0	1.83
MMLR
	4.16	0.006 (from s = 2)	2.43	24.28	0 (from s = 2)	2.47
wLRn
	2.81	0.019	1.92	14.02	0	2.12