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Parameter | Description | Early onset | Late-onset amyloid-first | Late-onset SNAP-first | Antiamyloid Rx (late-onset amyloid-first) |
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Aβ0 | Amyloid beta pathology, initial value | 0.05 | 0.01 | 0.01 | 0.01 |
τρ0 | Tau (amyloid-related) pathology, initial value | 0 | 0 | 0 | 0 |
τo0 | Tau (SNAP-related) pathology, initial value | 0 | 0.05 | 0.05 | 0.05 |
N0 | Neurodegeneration, initial value | 0 | 0 | 0 | 0 |
C0 | Cognitive impairment, initial value | 0 | 0 | 0 | 0 |
KΑβ | Amyloid beta pathology, carrying capacity | 1 | 1 | 1 | 1 |
Kτp | Tau (amyloid-related), carrying capacity | 1 | 1 | 1 | 1 |
KC | Cognitive impairment, carrying capacity | 1 | 1 | 1 | 1 |
KN | Neurodegeneration, carrying capacity | 1 | 1 | 1 | 1 |
λΑβ | Amyloid cascade, growth rate | 0.08 | 0.12 | 0.1 | 0.12 |
λΑβΑΟ | Amyloid pathology from amyloidopathy, growth rate | 0 | 0 | 0 | 0 |
δAβ | Amyloid degradation/clearance rate | 0 | 0 | 0 | 0.04 |
λτpβ | Tau (amyloid-related) from amyloid, growth rate | 0.025 | 0.025 | 0.025 | 0.025 |
λτp | Tau (amyloid-related) pathological cascade, growth rate | 0.05 | 0.05 | 0.05 | 0.05 |
λτoAS | Tau (SNAP-related) path from aging/SNAP, growth rate | 0.002 | 0.002 | 0.002 | 0.002 |
λC | Cognitive impairment cascade, growth rate | 0.05 | 0.05 | 0.05 | 0.05 |
λCΝ | Cognitive impairment from neurodegeneration, growth rate | 0.001 | 0.001 | 0.001 | 0.001 |
λCAS | Cognitive impairment from aging/SNAP, growth rate | 0 | 0 | 0 | 0 |
λCΕ | Cognitive impairment from genetic risk to growth rate | 0.001 | 0.001 | 0.001 | 0.001 |
λΝ | Neurodegeneration cascade, growth rate | 0.05 | 0.05 | 0.05 | 0.05 |
λΝτp | Neurodegeneration from tau (amyloid-related), growth rate | 0.025 | 0.025 | 0.025 | 0.025 |
λΝΤο | Neurodegeneration from tau (SNAP-related), growth rate | 0.0075 | 0.0075 | 0.0075 | 0.0075 |
λΝΑS | Neurodegeneration from aging/SNAP, growth rate | 0 | 0 | 0 | 0 |
AO | Amyloidopathy | 0 | 0 | 0 | 0 |
ARx | Age of onset of antiamyloid therapy | 0 | 0 | 0 | 65 |
AS | Aging, SNAP | 0 | 1 | 2 | 1 |
E | ApoE allele genetic risk | 0 | 0 | 0 | 0 |
R1 | Cognitive reserve (low risk) | 1 | 1 | 1 | 1 |
R2 | Cognitive reserve (high risk) | 25 | 25 | 25 | 25 |
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