The Effect of CT Scan Parameters on the Measurement of CT Radiomic Features: A Lung Nodule Phantom Study

Table 5

Effect of scan parameters on computer features in −630 HU phantom nodules.

Image features		Slice thickness						mAs		Reconstruction algorithm
		5.00 vs 1.25		5.00 vs 2.50		2.50 vs 1.25		30 vs 120		Lung vs standard
		Effect	d	Effect	d	Effect	d	Effect	d	Effect	d
Histogram	Mean	<	2.85	<	2.71	<	0.28	0	0.07	>	1.11
	Stddev	<	0.71	0	0.25	<	0.50	>	0.72	>	1.65
	Variance	<	0.74	0	0.35	<	0.55	>	0.68	>	1.20
	Skewness	<	1.15	<	1.25	0	0.19	<	0.61	<	1.04
	Kurtosis	>	0.40	>	0.63	<	0.16	>	0.58	>	2.77
	Energy	0	0.10	<	0.29	>	0.31	<	0.89	<	2.46
	Entropy	<	0.52	0	0.07	<	0.38	>	0.85	>	2.56
GLCM	Contrast	<	1.32	<	0.97	<	0.65	>	0.58	>	1.27
	Dissimilarity	<	1.21	<	0.74	<	0.56	>	0.65	>	1.67
	Homogeneity	>	0.69	>	0.16	>	0.40	<	0.79	<	2.81
	ASM	>	0.48	0	0.03	>	0.42	<	0.87	<	1.53
	Energy	>	0.55	0	0.08	>	0.41	<	0.87	<	1.80
	Probability max	>	0.34	0	0.06	0	0.26	<	0.76	<	1.21
	Entropy	<	0.63	0	0.20	<	0.41	>	0.75	>	1.72
	Correlation	>	1.20	>	0.80	>	0.65	<	0.58	<	1.21
GLRLM	LRE	>	0.40	0	0.08	>	0.34	<	0.79	<	2.12
	GLN	0	0.13	<	0.23	>	0.31	<	0.91	<	2.23
	RLN	<	0.46	0	0.02	<	0.34	>	0.83	>	2.27
	LGRE	>	0.98	>	1.49	0	0.35	0	0.21	0	0.13
	HGRE	<	2.89	<	2.64	<	0.44	>	0.20	>	1.09

and A is statistically smaller than B (A vs B); and A is statistically larger than B (A vs B); 0 indicates A and B are not statistically significant (A vs B). Cohen’s d: small ≥ 0.20; medium ≥ 0.50; large ≥ 0.80.