Multiple-Strain Malaria Infection and Its Impacts on <i>Plasmodium falciparum</i> Resistance to Antimalarial Therapy: A Mathematical Modelling Perspective

<div>Within-human dynamics of single- and multiple-strain dynamics of infected erythrocytes, gametocytes, and the immune cells in the absence preexisting immunity and with no antimalarial treatment (<span class="nowrap"><svg height="11.6217pt" id="M442" style="vertical-align:-3.272881pt" version="1.1" viewbox="-0.0498162 -8.34882 33.1356 11.6217" width="33.1356pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M615 290C615 392 563 448 529 448C511 448 491 441 484 434L483 425C518 400 546 349 546 273C546 158 504 46 417 46C381 46 356 77 356 142C356 184 380 293 392 334L387 340L307 323C305 288 296 228 287 188C265 94 221 52 180 52C144 52 112 89 112 171C112 278 164 372 241 430L226 454C106 394 23 288 23 155C23 40 79 -12 139 -12C184 -12 245 32 285 85C292 31 322 -12 376 -12C423 -12 470 18 501 45C570 104 615 184 615 290Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,7.969,3.132)"><path d="M319 325C317 349 306 409 297 431C277 440 250 449 209 449C117 449 57 389 57 319C57 243 122 209 182 182C232 159 261 135 261 91C261 48 227 21 190 21C130 21 85 79 68 145L41 140C41 104 51 36 58 22C75 7 121 -12 172 -12C252 -12 337 35 337 126C337 195 286 231 210 262C166 281 126 304 126 348C126 388 152 417 191 417C240 417 274 378 294 318L319 325Z"></path></g><g transform="matrix(.013,0,0,-0.013,15.451,0)"><path d="M535 323V373H52V323H535ZM535 138V188H52V138H535Z"></path></g><g transform="matrix(.013,0,0,-0.013,26.714,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g></svg>).</span> The rest of the model parameter values are in Table <a href="../tab3/">3</a>.</div>

Computational and Mathematical Methods in Medicine

fig12

Figure 12

Figure 12: Multiple-Strain Malaria Infection and Its Impacts on <i>Plasmodium falciparum</i> Resistance to Antimalarial Therapy: A Mathematical Modelling Perspective 

Figure 12 | Multiple-Strain Malaria Infection and Its Impacts on Plasmodium falciparum Resistance to Antimalarial Therapy: A Mathematical Modelling Perspective 