Table 2: Description of model parameters.

ParameterDescription

The rate of recruitment of red blood cells
Antimalarial treatment efficacy
Parasite strain-specific fitness cost
Background recruitment rate of immune cells
Hill parameters in , , and dynamics
Per capita natural mortality rate of unparasitized erythrocytes
Natural mortality rate of drug-sensitive IRBCs
Natural death rate of drug-resistant IRBCs
Rate of antimalarial eradication of merozoites and gametocytes, respectively
Death rate of drug-sensitive merozoites
Mortality rate of drug-resistant merozoites
Per capita mortality rate of drug-sensitive gametocytes
Mortality rate of drug-resistant gametocytes
Natural mortality rate of immune cells (CD8 + T cells)
βThe rate of infection of susceptible RBCs by blood floating merozoites
, Rate of formation of gametocytes from the infected RBCs
PNumber of merozoites produced per dying infected RBC
Immune cell proliferation rate due to IRBCs
Immune cell proliferation rate due to asexual merozoites
Immune cell proliferation rate due to gametocytes
Phagocytosis rate of IRBCs by immune cell
Phagocytosis rate of merozoites by immune cell
Phagocytosis rate of gametocytes by immune cell
Rate of development of resistance by drug-sensitive merozoites
Rate of development of resistance by drug-sensitive gametocytes
Accounts for the reduced fitness of the resistant parasite strains
γEfficiency of immune effector to inhibit merozoite infection
Half-saturation constant for , , and