HMMPred: Accurate Prediction of DNA-Binding Proteins Based on HMM Profiles and XGBoost Feature Selection

Table 4

Performance comparison on the PDB1075 dataset.

Methods	ACC	SN	SP	MCC	AUC
DNAbinder	0.7395	0.6857	0.7909	0.48	0.8140
DNA-Prot	0.7255	0.8267	0.5976	0.44	0.7890
iDNA-Prot	0.7540	0.8381	0.6473	0.50	0.7610
iDNA-Prot|dis	0.7730	0.7940	0.7527	0.54	0.8260
Kmer1+ACC	0.7523	0.7676	0.7376	0.50	0.8280
iDNAPro-PseAAC	0.7656	0.7562	0.7745	0.53	0.8392
PseDNA-Pro	0.7655	0.7961	0.7363	0.53	—
Local-DPP	0.7920	0.8400	0.7450	0.59	—
HMMBinder	0.8633	0.8707	0.8555	0.72	0.9026
Our method	0.8390	0.8398	0.8382	0.68	0.9018