Research Article
HMMPred: Accurate Prediction of DNA-Binding Proteins Based on HMM Profiles and XGBoost Feature Selection
Table 4
Performance comparison on the PDB1075 dataset.
| Methods | ACC | SN | SP | MCC | AUC |
| DNAbinder | 0.7395 | 0.6857 | 0.7909 | 0.48 | 0.8140 | DNA-Prot | 0.7255 | 0.8267 | 0.5976 | 0.44 | 0.7890 | iDNA-Prot | 0.7540 | 0.8381 | 0.6473 | 0.50 | 0.7610 | iDNA-Prot|dis | 0.7730 | 0.7940 | 0.7527 | 0.54 | 0.8260 | Kmer1+ACC | 0.7523 | 0.7676 | 0.7376 | 0.50 | 0.8280 | iDNAPro-PseAAC | 0.7656 | 0.7562 | 0.7745 | 0.53 | 0.8392 | PseDNA-Pro | 0.7655 | 0.7961 | 0.7363 | 0.53 | ā | Local-DPP | 0.7920 | 0.8400 | 0.7450 | 0.59 | ā | HMMBinder | 0.8633 | 0.8707 | 0.8555 | 0.72 | 0.9026 | Our method | 0.8390 | 0.8398 | 0.8382 | 0.68 | 0.9018 |
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