Research Article
HMMPred: Accurate Prediction of DNA-Binding Proteins Based on HMM Profiles and XGBoost Feature Selection
Table 5
Performance comparison on the independent dataset.
| Methods | ACC | SN | SP | MCC | AUC |
| DNAbinder | 0.6080 | 0.5700 | 0.6450 | 0.216 | 0.6070 | DNA-Prot | 0.6180 | 0.6990 | 0.5380 | 0.240 | — | iDNA-Prot | 0.6720 | 0.6770 | 0.6670 | 0.344 | — | iDNA-Prot|dis | 0.7200 | 0.7950 | 0.6450 | 0.445 | 0.7860 | Kmer1+ACC | 0.7096 | 0.8279 | 0.5913 | 0.431 | 0.7520 | iDNAPro-PseAAC | 0.7150 | 0.8276 | 0.6022 | 0.442 | 0.7780 | Local-DPP | 0.7900 | 0.9250 | 0.6560 | 0.625 | — | HMMBinder | 0.6902 | 0.6153 | 0.7634 | 0.394 | 0.6324 | Our method | 0.8118 | 0.9462 | 0.6774 | 0.648 | 0.8715 |
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