HMMPred: Accurate Prediction of DNA-Binding Proteins Based on HMM Profiles and XGBoost Feature Selection

Table 5

Performance comparison on the independent dataset.

Methods	ACC	SN	SP	MCC	AUC
DNAbinder	0.6080	0.5700	0.6450	0.216	0.6070
DNA-Prot	0.6180	0.6990	0.5380	0.240	—
iDNA-Prot	0.6720	0.6770	0.6670	0.344	—
iDNA-Prot|dis	0.7200	0.7950	0.6450	0.445	0.7860
Kmer1+ACC	0.7096	0.8279	0.5913	0.431	0.7520
iDNAPro-PseAAC	0.7150	0.8276	0.6022	0.442	0.7780
Local-DPP	0.7900	0.9250	0.6560	0.625	—
HMMBinder	0.6902	0.6153	0.7634	0.394	0.6324
Our method	0.8118	0.9462	0.6774	0.648	0.8715