Research Article
Modeling the Spatiotemporal Dynamics of Oncolytic Viruses and Radiotherapy as a Treatment for Cancer
Table 1
The parameters and their description, values, and units for models (
1) and (
7).
| Parameter | Description | Value | Units | Reference |
| | Diffusion coefficient of tumor cells | | mm2/h | Estimated | | Tumor growth rate | 0.02 | 1/h | [18] | | Infection rate of the virus | | mm3/h virus | [18] | | Death rate of infected tumor cells | 1/18 | 1/h | [18] | | Diffusion coefficient of viruses | | mm2/h | Estimated | | Burst size of free virus | 50 | Viruses/cell | [18] | | Consumption rate of the virus | 1 | Virus/cell | Estimated | | Clearance rate of the virus | 0.008 | 1/h | Estimated | | Rate of which the uninfected tumor cells become irreparably damaged | 0.01 | 1/h | Estimated | | Rate of which the infected tumor cells become irreparably damaged | 0.01 | 1/h | Estimated | | Death rate of damaged cells | 0.01 | 1/h | Estimated | | Radius of the blood vessel | 0.01 | mm | Estimated | BVF | Blood volume fraction | 0.05 | ā | [16] | | Value of at the blood vessel wall | | Viruses/mm3 | Estimated | | The time where Phase II begins | 120 | h | Estimated |
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