Modeling the Spatiotemporal Dynamics of Oncolytic Viruses and Radiotherapy as a Treatment for Cancer

Table 1

The parameters and their description, values, and units for models (1) and (7).

Parameter	Description	Value	Units	Reference
	Diffusion coefficient of tumor cells		mm^2/h	Estimated
	Tumor growth rate	0.02	1/h	[18]
	Infection rate of the virus		mm^3/h virus	[18]
	Death rate of infected tumor cells	1/18	1/h	[18]
	Diffusion coefficient of viruses		mm^2/h	Estimated
	Burst size of free virus	50	Viruses/cell	[18]
	Consumption rate of the virus	1	Virus/cell	Estimated
	Clearance rate of the virus	0.008	1/h	Estimated
	Rate of which the uninfected tumor cells become irreparably damaged	0.01	1/h	Estimated
	Rate of which the infected tumor cells become irreparably damaged	0.01	1/h	Estimated
	Death rate of damaged cells	0.01	1/h	Estimated
	Radius of the blood vessel	0.01	mm	Estimated
BVF	Blood volume fraction	0.05	—	[16]
	Value of at the blood vessel wall		Viruses/mm^3	Estimated
	The time where Phase II begins	120	h	Estimated