Holistic View on Cell Survival and DNA Damage: How Model-Based Data Analysis Supports Exploration of Dynamics in Biological Systems

Figure 1

Overview of different assays (clonogenic, comet, and immunocytochemical) capturing different aspects of DNA damage and repair (cell survival, physical damage, and molecular pathways). Each assay (left) provides data that correspond with a suitable model in silico (right). Alternatively, those various aspects can be captured in a single, holistic model from which synthetic assay data are derived for comparison. The latter approach is pursued in this work for emergent cell reactions (clonogenic assay) and physical DNA fragment repair (comet assay).