|
| Parameter (unit) | Description and sources | First patient | Second patient |
|
| | Tumor growth rate [40, 42]. | | |
| | Half saturation constant of the tumor killing rate [46]. | | |
| | 1/b is the tumor carrying capacity [40, 42]. | | |
| | Fractional no ligand-transduced tumor cell kill by natural killer cells [40, 42, 52]. | | |
| | Maximum tumor killing rate by cytokine [44, 46]. | | |
| | Saturation level of fractional tumor cell kill by CD8+T cells. Primed with ligand transduced cells, challenged with ligand transduced [40, 42, 52]. | | |
| | Fraction of circulating lymphocytes that become natural killer cells [40, 42]. | | |
| | Death rate of natural killer cells [40, 42]. | | |
| | Maximum natural killer cells recruitment by ligand transduced tumor cells [40, 42, 52]. | | |
| | Steepness of CD8+T cell recruitment curve by cytokine [40, 42]. | | |
| | Steepness coefficient of the natural killer cell recruitment curve [40, 42]. | | |
| | Maximum CD8+T cell recruitment rate. Primed with ligand transduced cells, challenged with ligand transduced cells [40, 42, 52]. | | |
| | Steepness coefficient of the CD8+T cell recruitment curve [40, 42, 52]. | | |
| | Fractional tumor cells kill by chemotherapy [40, 42]. | | |
| | Fractional natural killer cells kill by chemotherapy [40, 42]. | | |
| | Fractional CD8+T cells kill by chemotherapy [40, 42]. | | |
| | Fractional circulating lymphocytes cells kill by chemotherapy [40, 42]. | | |
| | Exponent of fractional tumor cell kill by CD8+T cells. Primed with ligand transduced cells, challenged with ligand transduced cells [40, 42]. | | |
| | Death rate of CD8+T cells [40, 42]. | | |
| | Natural killer cell inactivation rate by tumor cells [40, 42]. | | |
| | Maximum CD8+T cell recruitment rate by cytokine [40, 42]. | | |
| | CD8+T cell inactivation rate by tumor cells [40, 42]. | | |
| | Rate of which CD8+T cells are stimulated to be produced; as a result, tumor cells killed by natural killer cells [40, 42]. | | |
| | Rate of which CD8+T cells are stimulated to be produced; as a result, tumor cells interaction with circulating lymphocytes [40, 42]. | | |
| | Steepness coefficient of tumor-CD8+T cell lysis term D. Primed with ligand transduced cells, challenged with ligand transduced [40, 42]. | | |
| | Regulatory function by natural killer cells of CD8+T cells [40, 42]. | | |
| | Constant source of circulating lymphocytes [40, 42]. | | |
| | Half saturation constant of the CD4+T cells production rate [46, 53]. | | |
| | Half saturation constant of cytokine production rate [44, 46]. | | |
| | Natural death and differentiation of circulating lymphocytes [40, 42]. | | |
| | Maximum CD4+T cells production rate [44, 46]. | | |
| | Maximum production rate of cytokine [44, 46]. | | |
| | Rate of chemotherapy drug decay [40, 42]. | | |
| | Natural death rate of CD4+T cells [45, 46]. | | |
| | Rate of cytokine decay [40, 42]. | | |
| | Loss rate of CD4+T cells due to interaction with tumor cells [44, 46]. | | |
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