Computational and Mathematical Methods in Medicine

Research Article

Effects of Single-Nucleotide Polymorphisms in Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2): A Comprehensive Study

Table 2

Deleterious SNPs predicted from protein stability analysis and evolutionary conservation analysis.
SNPMutationEvolutionary conservationDDG and effect
rs1291358851F366YHighly conserved, exposedDestabilizing
rs1305210574V195AHighly conserved, exposed (f)Highly destabilizing
rs200059037V249MHighly conserved, buried (structural)Highly destabilizing
rs1307905721R311CHighly conserved, exposed (f)Highly destabilizing
rs1219582970W445CHighly conserved, buried (structural)Highly destabilizing
rs746740827Y183CConserved, exposedHighly destabilizing
rs746740827Y183TConserved, exposedHighly destabilizing
rs767392357L318AConserved, buriedHighly destabilizing
rs751909766I435AConserved, buriedHighly destabilizing
rs1459757320L419HConserved, buriedHighly destabilizing
rs769333324P389TConserved, exposed (functional)Highly destabilizing
rs1354124033V275TConserved, buriedHighly destabilizing
rs1275152562M265TConserved, buriedHighly destabilizing
rs1275152562M265DConserved, buriedHighly destabilizing