Mathematical Prostate Cancer Evolution: Effect of Immunotherapy Based on Controlled Vaccination Strategy
Table 1
Parameters of the PC mathematical model. According to this model, only two parameters r and are personalized and depend on the immunology system of the patients.
Definition
Value
Units
Rate of DC maturation following vaccine uptake
0.06
Number of vaccine cells required to induce maturation of one DC
1
—
Natural influx of mature DCs
0
cells
Rate of DC migration from skin to lymph node
0.027
Fraction of antigen-presenting DCs entering the lymph node
0.03
–
Rate of exhaustion of mature DCs
0.027
Death rate of exhausted DCs
0.014
Rate of inhibitory cell recruitment by exhausted DCs
Death rate of inhibitory cells
0.03
Rate of effector cell recruitment by mature DCs
0.38
Effector cell death rate
0.007
Rate of effector cell inactivation by inhibitory cells
