Research Article
A Computational Model to Investigate GABA-Activated Astrocyte Modulation of Neuronal Excitation
Table 2
Parameters used in the astrocyte model [
24,
28,
37].
| | Parameter | Description | Value |
| | Steady-state concentration of IP3 | 0.16 μM | | IP3 degradation constant | 7 s | | Rate of IP3 production via GABA | 0.1625 μM s-1 | | Rate of IP3 production via glutamate | 0.062 μM s-1 | | GABA Hill coefficient | 0.3 | | Glutamate Hill coefficient | 0.2 | | Dissociation constant for GABA-stimulated IP3 production | 0.6 μM | | Dissociation constant for glutamate-stimulated IP3 production | 0.78 μM | | Threshold for IP3 diffusion | 0.3 μM | | IP3 permeability | 0.09 μM s-1 | | Scaling factor of IP3 diffusion | 0.05 μM | | Ca2+ threshold for exocytosis | 0.2 μM | | Glutamate reintegration time constant | 1.66 s | | Resting glutamate release probability | 0.6 | | Volume ratio of vesicles to periastrocytic space | | | Clearance rate of astrocytic glutamate | 60 s-1 | | Total vesicular glutamate concentration | 200 mM | | GABA concentration-dependent proportionality coefficient | 0.3 |
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