Research Article
A Computational Model to Investigate GABA-Activated Astrocyte Modulation of Neuronal Excitation
Table 3
Parameters used in the synapse model [
28,
46].
| | Parameter | Description | Value |
| | Resting synaptic release probability | 0.3 | | Type and strength of astrocytes acting on presynapses | 0.8 | | Activation rate of astrocytic glutamate | 1.5 M-1 s-1 | | Inactivation rate of astrocytic glutamate | 0.2 s-1 | | GABAB forward rate constant | 16 μM-1 s-1 | | GABAB backward rate constant | 6 s-1 | | Facilitation time constant | 0.3 s | | Recovery time constant | 0.5 s | | Presynaptic glutamate clearance rate | 40 s-1 | | Vesicular to mixed volume ratio | 0.005 | | Total vesicular glutamate concentration | 500 mM | | AMPA forward rate constant | 1.1 μM-1 s-1 | | AMPA backward rate constant | 190 s-1 | | NMDA forward rate constant | 0.072 μM-1 s-1 | | NMDA backward rate constant | 6.6 s-1 | | GABAA forward rate constant | 0.53 μM-1 s-1 | | GABAA backward rate constant | 180 s-1 | | GABA reuptake rate constant | 6 s-1 |
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