An Integrating Immune-Related Signature to Improve Prognosis of Hepatocellular Carcinoma

Figure 8

The AUC of the combination in comparison with other known biomarkers [22, 23, 28, 30, 31, 48–51] in the validation dataset of TCGA-LIHC. Different colors represent the ROC curves of different biomarkers, and the relationships between them are shown in the right area of the figure. The upper curve represents the larger AUC and better predictive performance. The ensemble gene IDs and miRNA names stand for the single prognostic biomarker models, while the others stand for the combined prognostic biomarker models. The three-RNA model (The black curve) is the model proposed by our study, showing a significantly higher AUC than that of the other biomarkers. Meanwhile, the 7-miRNA model, the 3-gene model, and the 45-gene model were provided by Zhang et al. [48], Li et al. [22], and Gillet et al. [23], respectively.