Broad Learning Enhanced ¹H-MRS for Early Diagnosis of Neuropsychiatric Systemic Lupus Erythematosus

Table 5

Changes of major metabolite features detected in ¹H-MRS in NPSLE patients vs. healthy controls.

Brain region	Metabolites	HCs ()	NPSLE ()	value	AUC
RPCG	Cr			0.274	0.591
	PCr			0.035	0.588
	Cr+PCr			0.391	0.432
	NAA			0.478	0.457
	NAAG			0.848	0.548
	NAA+NAAG			0.183	0.283
	NAA+NAAG/Cr+PCr			0.086	0.62
	mI			0.274	0.557
	mI/Cr+PCr			0.165	0.567
	Cho+PCh			0.039	0.492
	Cho+PCh/Cr+PCr			0.249	0.466
	Glu+Gln			0.322	0.398
	Glu+Gln/Cr+PCr			0.953	0.389
LPCG	Cr			0.442	0.485
	PCr			0.825	0.435
	Cr+PCr			0.225	0.41
	NAA			0.104	0.401
	NAAG			0.249	0.444
	NAA+NAAG			0.005	0.66
	NAA+NAAG/Cr+PCr			0.006	0.658
	mI			0.009	0.62
	mI/Cr+PCr			0.132	0.413
	Cho+PCh			0.636	0.391
	Cho+PCh/Cr+PCr			0.076	0.457
	Glu+Gln			0.595	0.682
	Glu+Gln/Cr+PCr			0.745	0.457
RDT	Cr			0.859	0.535
	PCr			0.008	0.694
	Cr+PCr			0.001	0.747
	NAA			0.002	0.76
	NAAG			0.058	0.576
	NAA+NAAG			0.636	0.435
	NAA+NAAG/Cr+PCr			0.004	0.639
	mI			0.496	0.66
	mI/Cr+PCr			0.041	0.766
	Cho+PCh			0.001	0.776
	Cho+PCh/Cr+PCr			0.79	0.5
	Glu+Gln			0.767	0.478
	Glu+Gln/Cr+PCr			0.767	0.457
LDT	Cr			0.221	0.591
	PCr			0.188	0.435
	Cr+Cr			0.274	0.457
	NAA			0.076	0.639
	NAAG			0.002	0.673
	NAA+NAAG			0.255	0.598
	NAA+NAAG/Cr+PCr			0.003	0.735
	mI			0.002	0.60
	mI/Cr+PCr			0.002	0.779
	Cho+PCh			0.002	0.685
	Cho+PCh/Cr+PCr			0.929	0.435
	Glu+Gln			0.001	0.548
	Glu+Gln/Cr+PCr			0.615	0.629
RLN	Cr			0.005	0.648
	PCr			0.001	0.673
	Cr+PCr			0.478	0.5
	NAA			0.359	0.5
	NAAG			0.515	0.5
	NAA+NAAG			0.225	0.5
	NAA+NAAG/Cr+PCr			0.478	0.5
	mI			0.036	0.5
	mI/Cr+PCr			0.701	0.603
	Cho+PCh			0.003	0.588
	Cho+PCh/Cr+PCr			0.003	0.598
	Glu+Gln			0.231	0.482
	Glu+Gln/Cr+PCr			0.836	0.432
LLN	Cr			0.107	0.457
	PCr			0.008	0.641
	Cr+PCr			0.076	0.501
	NAA			0.953	0.504
	NAAG			0.124	0.526
	NAA+NAAG			0.722	0.557
	NAA+NAAG/Cr+PCr			0.88	0.651
	mI			0.894	0.5
	mI/Cr+Cr			0.036	0.478
	Cho+PCh			0.007	0.601
	Cho+PCh/Cr+PCr			0.001	0.541
	Glu+Gln			0.132	0.435
	Glu+Gln/Cr+PCr			0.344	0.5
RI	Cr			0.005	0.603
	PCr			0.193	0.5
	Cr+PCr			0.478	0.5
	NAA			0.023	0.457
	NAAG			0.124	0.5
	NAA+NAAG			0.615	0.5
	NAA+NAAG/Cr+PCr			0.261	0.5
	mI			0.209	0.466
	mI/Cr+PCr			0.626	0.5
	Cho+PCh			0.329	0.603
	Cho+PCh/Cr+PCr			0.425	0.5
	Glu+Gln			0.461	0.5
	Glu+Gln/Cr+PCr			0.359	0.5
RPWM	Cr			0.442	0.5
	PCr			0.008	0.5
	Cr+PCr			0.859	0.5
	NAA			0.657	0.5
	NAAG			0.274	0.5
	NAA+NAAG			0.174	0.5
	NAA+NAAG/Cr+PCr			0.723	0.5
	mI			0.329	0.5
	mI/Cr+PCr			0.165	0.622
	Cho+PCh			0.132	0.495
	Cho+PCh/Cr+PCr			0.01	0.576
	Glu+Gln			0.261	0.432
	Glu+Gln/Cr+PCr			0.104	0.535
LPWM	Cr			0.005	0.726
	PCr			0.375	0.735
	Cr+PCr			0.79	0.704
	NAA			0.813	0.457
	NAAG			0.036	0.5
	NAA+NAAG			1	0.5
	NAA+NAAG/Cr+PCr			0.225	0.5
	mI			0.033	0.516
	mI/Cr+PCr			0.679	0.548
	Cho+PCh			0.132	0.603
	Cho+PCh/Cr+PCr			0.091	0.603
	Glu+Gln			0.515	0.5
	Glu+Gln/Cr+PCr			0.813	0.5

Metabolites with significant difference (). Metabolites for our model. Metabolites for our model and metabolites with significant difference ().