Gene Expression Profiling of Type 2 Diabetes Mellitus by Bioinformatics Analysis

Table 1

The candidate genes selected from the protein-protein interaction network.

Core genes			Gene IDs
Cluster	Nodes	Edges
1	15	104	AVPR1B CYSLTR2 EDN3 GHSR GNG3 GRM5 KALRN LTB4R2 MLN NMBR NPFFR2 PIK3R1 PTGFR SAA1 TBXA2R
2	13	78	ASB11 FBXL18 FBXL7 FBXO17 FBXO7 GLMN KLHL41 RNF7 UBE2H UBE2L6 UBE2V1 ZNF645 ZNRF1
3	8	28	CCL20 CXCL3 DRD2 GNAI1 HRH4 NPY2R PTGER3 TAS2R46
4	8	28	ARMC8 CYFIP1 DEFA4 DNASE1L1 HP LTF OLFM4 VCL
5	8	28	CEACAM5 GP2 LY6G6C LY6H LY6K LYPD4 LYPD5 PRSS21
6	6	14	COL19A1 COL25A1 COL4A6 COL9A1 PLOD2 PPIB
7	5	10	CGA FSHB GLP2R GPR45 HTR4
8	10	22	APOA2 BCAR1 BMP4 EVA1A ITGB1 ITGB3 MEN1 MET TMEM132A TNC
9	17	35	ARF6 BDNF CDC42 CFTR FZD4 GBP6 GNAZ HLA-C HLA-DRB1 HLA-DRB5 ITSN2 NGFR NTRK2 RAC1 SNX9 SYT9 TRIM62
Hub genes			AKT1 CDC42 CREBBP GNAI1 GNG3 GRM5 ITGB1 KALRN PIK3R1 RAC1 SAA1 TBXA2R
Bottleneck genes			AKT1 CDC42 CEACAM8 CREBBP GNAI1 GNG3 ITGB1 MAP2K3 PIK3R1 PSMB8 RAC1 RFC2 UBE2L6 UBE2V1

Candidate genes are shown in bold.