Computational and Mathematical Methods in Medicine

Computational and Mathematical Methods in Medicine / 2020 / Article

Research Article | Open Access

Volume 2020 |Article ID 9676501 | 12 pages | https://doi.org/10.1155/2020/9676501

Ergodic Stationary Distribution of a Stochastic Hepatitis B Epidemic Model with Interval-Valued Parameters and Compensated Poisson Process

Academic Editor: Konstantin Blyuss
Received16 Mar 2019
Revised16 Nov 2019
Accepted26 Nov 2019
Published22 Jan 2020

Abstract

Hepatitis B epidemic was and is still a rich subject that sparks the interest of epidemiological researchers. The dynamics of this epidemic is often modeled by a system with constant parameters. In reality, the parameters associated with the Hepatitis B model are not certain, but the interval in which it belongs to can readily be determined. Our paper focuses on an imprecise Hepatitis B model perturbed by Lévy noise due to unexpected environmental disturbances. This model has a global positive solution. Under an appropriate assumption, we prove the existence of a unique ergodic stationary distribution by using the mutually exclusive possibilities lemma demonstrated by Stettner in 1986. Our main effort is to establish an almost perfect condition for the existence of the stationary distribution. Numerical simulations are introduced to illustrate the analytical results.

1. Introduction

Hepatitis B is an enormous defiance and a great global health issue caused by the Hepatitis B virus (HBV) [2]. Chronic HBV can be transmitted by sexual contact, through the touch, by impregnation with polluted blood, or by the direct transmission of Hepatitis B from the mother to a fetus during pregnancy (vertical transmission) [3]. According to the recent statistics of world health organization (WHO) [4], about 350 million people worldwide have been infected and carrying HBV. This serious infection is responsible for approximately 600,000 deaths each year [5]. Because of the high severity of HBV infection and a large number of deaths associated with it, it is compulsory to improve our control of this virus. Mathematical models are a vigorous tool to simulate and control the spread of the HBV infection. There exist many previous interesting works committed to studying Hepatitis B transmission. For example, Anderson and May [6] analyzed a straightforward mathematical model for illustrating the role of carrier individuals on the spread of HBV. In [7, 8], the authors developed the impact of vaccination and other controlling measures of HBV outbreak. They showed that the booster vaccine of Hepatitis B is very necessary and useful. Khan et al. [9] formulated the characteristics of HBV disease transmission and proposed the following deterministic Susceptible (S)—Infected (I)—Recovered (R) model:with initial data , , and . The positive parameters of the deterministic model (1) are given in the following list. The deterministic model constructed above can be improved by taking into account the unpredictable biological conditions [1014]. Also, environmental fluctuations have important effects on the growth and propagation of an epidemic disease [15, 16]. Khan et al. [9] discussed the dynamics of a stochastic Hepatitis B epidemic model with varying population size. They supposed that the effect of the random fluctuations is manifested as a perturbation in the Hepatitis B transmission rate. To confer the realistic aspect to our study and make it biologically reasonable, in this study, we extend the work of Khan et al. [9] to the case of Lévy noise perturbation. We take into consideration the effects due to some unexpected and severe environmental disturbances (tsunami, floods, earthquakes, hurricanes, whirlwinds, etc.) on the disease outbreak [17, 18]. Thus, we consider the following model:where and are the left limits of and , respectively. is a real-valued Brownian motion with intensity defined on a complet probablity space with a filtration satisfying the usual conditions. N is a Poisson counting measure with the compensator and the characteristic measure ν on a measurable subset Z of satisfying . is independent of N. We assume that ν is a Lévy measure such that . The bounded function is -measurable and continuous with respect to ν.

In system (2), we assume that model parameters (see Table 1) are precisely known and constant. However, this hypothesis may not be validated due to the lack of data and errors of measurements. It is more realistic to study Hepatitis B dynamics with interval-valued parameters. Recently, Pal et al. [19] used interval-valued parameters to analyze the prey-predator model due to the lack of precise biological data such as prey and predator population growth rates. The same logic was applied for epidemic models. In [20], the authors treated a cholera epidemic model with uncertain parameters. They investigated the stability condition of equilibrium points. Bao et al. [21] studied a stochastic SIRS model that includes Lévy jumps and interval parameters. They established the stochastic threshold which determines the extinction and persistence in the mean of disease. In [22], the authors studied an imprecise SIR epidemic model. They solved the optimal control problem.


ParametersInterpretation

AThe recruitment rate corresponding to births and immigration.
μThe natural mortality rate.
βThe transmission rate.
δThe rate of individuals leaving I to R.
rThe disease-related death rate.
θThe successful vaccination rate.

In this paper, we consider the Hepatitis B epidemic model with stochastic transmissions and Lévy noise. To make our model more realistic, we consider imprecise biological parameters. To the best of our knowledge, the existence of a stationary distribution of system (2) with imprecise parameters remains not proved. In the next section, we propose a solution to the mentioned problem by considering an original method different from the Lyapunov approach described in [23]. Before proving the existence of unique a stationary distribution in Subsection 2.3, we demonstrate the well-posedness of the model (2) with interval-valued parameters in Subsection 2.2. Simulation examples are proposed in Subsection 2.4 to illustrate our theoretical study.

2. Main Results

2.1. Imprecise Stochastic Hepatitis B Model

Before showing the main result of this paper, we first present some definitions of interval numbers and interval-valued functions which are used in our study. Then, we construct the imprecise stochastic Hepatitis B model.

Definition 1 (see [19]). An interval number Z is defined as where is the set of all real numbers and and are the lower and upper limits of the interval numbers, respectively. Furthermore, any real number z can be represented in terms of interval number as .

Definition 2 (see [19]). An interval-valued function for the interval can be represented by the following function:

Theorem 1. The following stochastic differential equation with interval-valued parameterswhere , , , , , and , is provided an interval-valued functional form of parameters by the following stochastic differential equation (SDE):for .
The proof is similar to that in [19] and hence is omitted.

2.2. Well-Posedness of the Stochastic Model (5)

To investigate the dynamical behavior of the model (5), the first concerning thing is whether the model is well-posed. Theorem 2 is a prerequisite for analyzing the long-run behavior of the model (5). From epidemiological considerations, it is reasonable to suppose that the intensity of Lévy jumps cannot exceed environmental carrying capacity. Hence, we impose the following standard assumption:

Assumption 1. The function is bounded and , .
By using the Lyapunov analysis method (as mentioned in [21]), we shall verify that the solution of system (5) is global and positive.

Theorem 2. For any initial value , there exists a unique positive solution of system (5) on , and the solution will remain in with probability one. That is to say, the solution for all almost surely.

Proof. Since the coefficients of system (5) satisfy the local Lipschitz condition, then for any initial value , there is a unique local solution on , where is the explosion time. To show that the solution is global, we only need to prove that a.s. Let be sufficiently large such that , , lying within the interval . For each integer , we define the following stopping time:where, throughout this paper, we set (as usual, denotes the empty set). Clearly, is increasing as . Set whence . If we can prove that a.s., then and the solution for all almost surely. Specifically, to complete the proof, all we need is only to prove that a.s. If this statement is false, then there exists a pair of positive constants and such thatHence, there is an integer such thatFor and each ϵ,Then,Define the following Lyapunov function byObviously, this function is nonnegative which can be seen from for .
For , using Itô’s formula, we obtain thatwhere is the differential operator, andwhere By assumption 1, we have . In addition, by Taylor–Lagrange’s formula, we show thatSimilarly, we getTherefore,where is a positive constant. Integrating both sides of (12) from 0 to , and taking expectation, we getSetting for and by (8), we have . For , there is some component of , , and equals either ϵ or . Hence, is not less than or . Consequently,Extending ϵ to leads to the contradiction. Thus, a.s. which completes the proof of the theorem.
Remark 2.5. From mathematical and biological considerations, we can study the disease dynamics of the model (5) in the following bounded set:Therefore, the region is almost surely positively invariant set by system (5).

2.3. Existence and Uniqueness of a Stationary Distribution to System (5)

Our aim in this subsection is to give the appropriate condition for the SDE model (5) which has a unique ergodic stationary distribution. To this end, we introduce the following lemma known as mutually exclusive possibilities. It was proved by Stettner [1].

Lemma 1 (see [1]). Let be a stochastic Feller process, then either an ergodic probability measure exists, orwhere the supremum is taken over all initial distributions ν on and is the probability for with .
For convenience, we introduce the following notation. Letwhere .
For the ergodicity of system (5), we have the following result.

Theorem 3. If , the stochastic system (5) admits a unique stationary distribution and it has the ergodic property for any initial value .

Proof. The following proof is divided into three steps:Step I. Similar to the proof of Lemma 3.2 in [24] or Theorem 2.5 in [25], we briefly verify the Feller property of the SDE model (5). The main purpose of the next steps is to prove that (21) is impossible.Step II. DefineApplying Itô’s formula givesNoting that , the equality (24) can be rewritten as follows:Integrating the inequality (25) from 0 to t leads towhereThe quadratic variation of is defined by . Therefore, we getSimilarly, we haveBy the assumption 1, we deduce thatThenAccording to the strong law of large numbers for local martingales [26], one can conclude thatBy using (16) and assumption 1, we getLetTherefore,Thus, we can derive thatStep III. To continue our analysis, we need to set the following subsets:where is a positive constant to be determined later. It then follows from (36) thatWe can choosethen, we obtainLet a and b two real numbers greater than 1 such that . By utilizing Young inequality for all x, , we getwhere ϖ is a positive constant satisfyingFrom (41), we deduce thatSettingwhere is a positive constant to be explained in the following. By using the Tchebychev inequality, we can observe thatChoosingWe thus obtainAccording to (43), one can derive thatBased on the above analysis, we have determined a compact domain such thatApplying similar arguments to those in [24], we show the uniqueness of the ergodic stationary distribution of our model (5), denoted by . This completes the proof.

2.4. Numerical Simulations

In this subsection, in order to show different dynamical results of the stochastic model (2) under imprecise parameter values, we present some numerical simulations. We use Milstein’s method to simulate the trajectories of the stochastic model (5). The parameters values are given in the following list. For the purpose of showing the effects of imprecise parameters and Lévy noise on Hepatitis B dynamics, we have realized the simulation 10000 times. We assume that , , and . Then, we obtain the following results: noticing that the assumption 1 is always held with parameters’ value in Table 2. From Figures 13, we show the existence of the unique stationary distributions for , , and of model (5) at , where the smooth curves are the probability density functions of , , and , respectively. It can be obviously observed that the solution of the SDE model (5) persists in the mean. Furthermore, different values of the parameter imprecision p can also crucially affect the persistence of Hepatitis B (see Table 3).


NotationValueSourceNotationValue

0.4[9]0.6
0.09[9]0.2
0.1[9]0.2
0.3[9]0.5
0.1[9]0.3
0.2Assumed0.3
0.08Assumed0.1