MicroRNA-603 Promotes Progression of Cutaneous Melanoma by Regulating TBX5

Figure 4

TBX5 is less expressed in melanoma cells and is a direct regulatory target of microRNA-603. (a) The targeting binding site of microRNA-603 and TBX5 3UTR; (b) schematic diagram of luciferase reporter plasmids TBX5-WT and TBX5-MUT; (c) the mRNA and protein expression levels of TBX5 in human normal melanocyte cell line PIG1 and melanoma cell lines Malme-3M and A375; (d) the targeted binding of microRNA-603 and TBX5; (e) the effect of abnormal expression level of microRNA-603 on the mRNA expression of TBX5; (f) the influence of abnormal expression level of microRNA-603 on protein expression of TBX5. means .

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