circFAT1(e2) Inhibits Cell Apoptosis and Facilitates Progression in Vascular Smooth Muscle Cells through miR-298/MYB Axis

<div>circFAT1(e2) promoted MYB expression by sponging miR-298. (a, b) Luciferase reporter assay showed an interaction between miR-298 and circFAT1(e2) or MYB <span class="nowrap"><svg height="11.6425pt" id="M32" style="vertical-align:-0.2063999pt" version="1.1" viewbox="-0.0498162 -11.4361 10.1586 11.6425" width="10.1586pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M285 378C315 398 338 416 353 432C373 451 384 474 384 503C384 579 325 635 236 635H235C182 635 136 610 108 579L65 516L85 496C110 533 150 575 205 575C258 575 300 543 300 481C300 407 232 369 141 339L147 310C163 315 188 321 211 321C268 321 338 284 338 192C338 94 288 40 217 40C160 40 119 68 93 91C85 98 77 97 69 91C60 84 47 71 46 58C44 46 48 35 62 22C75 10 116 -12 162 -12C234 -12 424 62 424 224C424 297 373 359 285 376V378Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,6.24,-5.741)"><path d="M310 541L304 571C290 586 211 619 185 610L80 76L131 52L310 541Z"></path></g></svg>-</span>UTR. HASMC cells were cotransfected with luciferase reporter and miR-298 mimics. (c) circFAT1(e2) knockdown resulted in elevated expression of miR-298 in HUASMC and HASMC cells. 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Computational and Mathematical Methods in Medicine

fig2

Figure 2

Figure 2: circFAT1(e2) Inhibits Cell Apoptosis and Facilitates Progression in Vascular Smooth Muscle Cells through miR-298/MYB Axis 