Establishment of an Immune-Related Gene Signature for Risk Stratification for Patients with Glioma

Figure 6

Establishment of an IRRS model in the TCGA cohort. (a) The distribution of risk score in glioma patients based on the IRRS model and survival status of each glioma patient, as well as a heat map of four DE IRG expressions in high- and low-risk groups. (b) ROC curves at 1-year (AUC: 0.86), 3-year (AUC: 0.855), and 5-year (AUC: 0.812) time points for predicting its prognostic performance in patients with glioma. (c) Survival curve reveals high-risk score patients associated with unfavorable outcome, with a 5-year survival rate of roughly 14.3%. (d) Multivariate Cox regression analysis discovers the potentiality of this IRRS model as an independent prognostic factor (, 95% CI: 1.252-2.85, ). IRRS: immune-related risk score; TCGA: The Cancer Genome Atlas; DE IRGs: differentially expressed immune-related genes; AUC: area under the curve; OS: overall survival; ROC: receiver operating characteristic.

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