Establishment of an Immune-Related Gene Signature for Risk Stratification for Patients with Glioma

Figure 7

Validation of the IRRS model in the CGGA dataset. (a) The distribution of risk score, survival status of every patient with glioma, and heat map of four DE IRGs. (b) ROC curves of this IRRS prognostic model for evaluating the predictive probability for gliomas’ 1-year (AUC: 0.715), 3-year (AUC: 0.772), and 5-year (AUC: 0.759) OS. (c) KM curve indicates glioma patients with high risk has dismal prognosis, with 5-year survival rate of nearly 29.8%. (d) Multivariate Cox regression analysis for the risk score and clinical characteristics denotes a superior prognostic value of the IRRS model for glioma patients (, 95% CI: 1.493-3.14, ). IRRS: immune-related risk score; CGGA: Chinese Glioma Genome Atlas; DE IRGs: differentially expressed immune-related genes; AUC: area under the curve; OS: overall survival; KM: Kaplan-Meier; ROC: receiver operating characteristic.

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