Establishment of an Immune-Related Gene Signature for Risk Stratification for Patients with Glioma

Table 5

Univariate and multivariate Cox regression analyses for the IRRS model and clinical traits.

Variables	Univariate cox analysis						Multivariate cox analysis
	TCGA			CGGA			TCGA			CGGA
	HR; (95% CI)	value	C-index; (95% CI)	HR; (95% CI)	value	C-index; (95% CI)	HR; (95% CI)	value	C-index; (95% CI)	HR; (95% CI)	value	C-index; (95% CI)
Age	4.89 (3.772-6.33)	<0.0001	0.671 (0.640-0.702)	3.15 (2.269-4.39)	8.25-12	0.581 (0.554-0.608)	2.02 (1.450-2.81)	3.20-05	0.847 (0.823-0.871)	1.21 (0.821-1.79)	0.3349	0.765 (0.732-0.798)
Gender	1.26 (0.986-1.61)	0.0645	0.533 (0.500-0.566)	1.16 (0.875-1.53)	0.309	0.506 (0.471-0.541)	—	—		—	—
Grade	9.23 (7.095-12.01)	<0.0001	0.736 (0.709-0.763)	4.20 (2.851-6.17)	3.43-13	0.638 (0.609-0.667)	2.54 (1.750-3.69)	9.50-07		3.05 (1.916-4.86)	2.61-06
Risk score	6.53 (4.960-8.59)	<0.0001	0.743 (0.719-0.767)	3.85 (2.857-5.19)	<0.0001	0.661 (0.630-0.692)	1.89 (1.252-2.85)	2.40-03		2.17 (1.493-3.14)	4.63-05
IDH_status	8.76 (6.708-11.43)	<0.0001	0.782 (0.758-0.806)	4.42 (3.278-5.96)	<0.0001	0.699 (0.672-0.726)	2.70 (1.700-4.28)	2.51-05		2.85 (1.966-4.14)	3.46-08
MGMT_status	3.17 (2.430-4.13)	<0.0001	0.654 (0.619-0.689)	1.36 (1.009-1.82)	0.0434	0.528 (0.489-0.567)	1.29 (0.938-2.78)	0.1168		1.20 (0.884-1.64)	0.2389

HR: hazard ratio; IRRS: immune-related risk score; TCGA: The Cancer Genome Atlas; CGGA: Chinese Glioma Genome Atlas; IDH: isocitrate dehydrogenase; MGMT: O-6-methylguanine-DNA methyltransferase; bold texts indicate statistically significant difference.