Computational and Mathematical Methods in Medicine / 2021 / Article / Tab 1 / Research Article
Identification of a Transcription Factor Signature That Can Predict Breast Cancer Survival Table 1 The Cox regression analysis of the association between clinicopathological factors (including risk scores) and the disease-free survival of BRCA patients.
Variables Group Patients ( ) Univariate analysis Patients ( ) Multivariate analysis HR (95% CI) HR (95% CI) TCGA Risk score Low/high 475/475 4.18 (2.50-6.97) 418/411 4.40 (2.31-8.39) Age ≤50/>50 290/660 0.67 (0.43-1.03) 251/578 0.66 (0.39-1.11) Pathologic stage I-II/III-IV 723/216 3.34 (2.15-5.19) 645/184 4.28 (2.49-7.34) ER status N/P 214/697 0.49 (0.31-0.77) 191/638 1.35 (0.32-5.61) PR status N/P 304/604 0.46 (0.30-0.71) 274/555 0.56 (0.26-1.19) HER2 status N/P 680/160 0.93 (0.47-1.82) 671/158 0.72 (0.30-1.69) Triple negative No/yes 804/146 1.62 (0.97-2.71) 685/144 1.89 (0.43-8.35) GSE20685 Risk score Low/high 164/163 2.41 (1.58-3.68) 164/158 2.22 (1.43-3.43) Age ≤50/>50 209/118 0.74 (0.48-1.14) 206/116 0.79 (0.49-1.27) T stage I-II/III-IV 101/188 1.93 (1.50-2.49) 100/186 1.22 (0.86-1.74) N stage N0/N1-3 137/190 3.73 (2.26-6.15) 135/187 3.46 (1.99-6.01) M stage M0/M1 319/8 21.96 (10.49-45.99) 315/7 5.78 (2.02-16.58) Adjacent CT No/yes 54/268 2.07 (1.07-3.99) 54/268 1.34 (0.65-2.76) GSE21653 Risk score Low/high 126/126 2.83 (1.77-4.53) 115/113 3.04 (1.80-5.11) Age ≤50/>50 92/160 1.14 (0.72-1.79) 81/147 1.31 (0.79-2.17) T stage I-II/III-IV 178/66 1.70 (1.06-2.73) 164/64 1.20 (0.72-2.01) N stage N0/N1-3 116/133 1.54 (0.98-2.40) 105/123 1.61 (0.97-2.69) ER status N/P 110/140 0.66 (0.43-1.02) 100/128 0.46 (0.17-1.26) PR status N/P 124/126 0.84 (0.55-1.30) 114/114 1.43 (0.60-3.38) HER2 status N/P 207/26 1.59 (0.84-3.03) 204/24 1.09 (0.42-2.85) Triple negative No/yes 160/85 1.19 (0.74-1.89) 145/83 0.88 (0.26-2.90) GSE42568 Risk score Low/high 52/52 3.68 (1.97-6.88) 51/50 4.18 (2.13-8.17) Age ≤50/>50 27/77 0.66 (0.36-1.21) 25/76 0.72 (0.36-1.46) N stage N0/N1-3 45/59 4.35 (2.16-8.76) 44/57 4.72 (2.24-9.95) ER status N/P 34/67 0.44 (0.24-0.79) 34/67 0.40 (0.21-0.77)
HR: hazard ratio; CI: confidence interval; ER: estrogen receptor; PR: progesterone receptor; HER2/erbb2: epidermal growth factor receptor 2; Adjacent CT: adjacent chemotherapy; N: negative; P: positive.