Characteristics Intervention group ( ) Control group ( ) / /Age, years, median (IQR) 66 (62-68) 64 (59-68) -1.514 0.130 Sex, (%) Male 36 (92.3) 34 (87.2) 0.557 0.711 Female 3 (7.7) 5 (12.8) BMI, kg/m2 , mean (SD) 1.069 0.289 Disease course, month, median (IQR) 72 (36-120) 64 (21-178) -0.510 0.610 Relevant family history, (%) 1 (2.6) 0 (0.0) 1.013 1.000 Drug allergy history, (%) 2 (5.1) 1 (2.6) 0.347 1.000 Care level, (%) 1.107 1.000 I 1 (2.6) 0 (0.0) II 9 (23.1) 9 (23.1) III 27 (69.2) 28 (71.8) IV 2 (5.1) 2 (5.1) Family average annual , (%) 13 (34.2) 15 (38.5) 0.150 0.814 Profession, (%) 0.217 0.816 Retire 23 (59.0) 25 (64.1) Others 16 (41.0) 14 (35.9) Current smoking, (%) 25 (64.1) 23 (59.0) 0.217 0.816 Payment of medical expense, (%) 0.963 0.462 Medical insurance 25 (64.1) 29 (74.4) Self-expense/partial expense 14 (35.9) 10 (25.6) Education degree, (%) 0.396 0.908 Primary school 12 (30.8) 11 (28.2) Junior high school 21 (53.8) 20 (51.3) Senior high school 6 (15.4) 8 (20.5) Marriage status, (%) Married 39 (100.00) 39 (100.00) Single 0 (0.0) 0 (0.0) Breathing function exercise history, (%) 0 (0.0) 1 (2.6) 1.013 1.000 Complications and drugs, (%) 3 (7.7) 2 (5.1) 0.214 1.000 SpO2, median (IQR) 96 (95-97) 96 (95-97) -0.068 0.946 Hospital day, , median (IQR) 6 (6-8) 7 (6-8) -0.475 0.635