Research Article
[Retracted] Protumor Effects of Histone H3–H4 Chaperone Antisilencing Feature 1B Gene on Lung Adenocarcinoma: In Silico and In Vitro Analyses
Table 2
Cox regression analysis for the association of overall survival of LUAD patients with clinical characteristics and the mRNA expression level of ASF1B.
| | Characteristics | Total () | Univariate analysis | Multivariate analysis | | HR (95% CI) | value | HR (95% CI) | value |
| | T stage (T3&T4 vs. T1&T2) | 523 | 2.317 (1.591-3.375) | <0.001 | 2.256 (0.874-5.823) | 0.093 | | N stage (N1&T2 vs. N0) | 437 | 2.386 (1.698-3.352) | <0.001 | 1.716 (1.066-2.764) | 0.026 | | M stage (M1 vs. M0) | 377 | 2.136 (1.248-3.653) | 0.006 | 1.856 (0.382-9.011) | 0.443 | | Pathologic stage (stage III&stage IV vs. stage I&stage II) | 518 | 2.664 (1.960-3.621) | <0.001 | 0.988 (0.271-3.604) | 0.985 | | Primary therapy outcome (PD&SD vs. PR&CR) | 439 | 2.653 (1.888-3.726) | <0.001 | 2.086 (1.281-3.395) | 0.003 | | Gender (male vs. female) | 526 | 1.070 (0.803-1.426) | 0.642 | | | | Race (Asian&Black or African-American vs. White) | 468 | 0.678 (0.415-1.109) | 0.121 | | | | Smoker (yes vs. no) | 512 | 0.894 (0.592-1.348) | 0.591 | | | | Age (>65 vs. ≤65) | 516 | 1.223 (0.916-1.635) | 0.172 | | | | Number_pack_years_smoked (≥40 vs. <40) | 363 | 1.073 (0.753-1.528) | 0.697 | | | | Anatomic neoplasm subdivision (right vs. left) | 512 | 1.037 (0.770-1.397) | 0.810 | | | | Anatomic neoplasm subdivision (peripheral lung vs. central lung) | 182 | 0.913 (0.570-1.463) | 0.706 | | | | ASF1B expression (high vs. low) | 526 | 1.503 (1.125-2.007) | 0.006 | 1.643 (1.036-2.606) | 0.035 |
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