Research Article
Research for Expression and Prognostic Value of GABRD in Colon Cancer and Coexpressed Gene Network Construction Based on Data Mining
Table 1
Networks of kinase, miRNA, and transcription factor targets of GABRD.
| Networks | Gene set | Description | Size | Leading edge number | ES | NES | value | FDR |
| Kinase target | Kinase_WEE1 | WEE1 G2 checkpoint kinase | 5 | 4 | -0.92033 | -1.7192 | 0.0070922 | 0.17746 | Kinase_NEK2 | NIMA-related kinase 2 | 8 | 5 | -0.74354 | -1.746 | 0.021053 | 0.18368 | Kinase_PKM | Pyruvate kinase, muscle | 4 | 2 | -0.95009 | -1.7604 | ≤0.001 | 0.235 | Kinase_CSNK1G2 | Casein kinase 1 gamma 2 | 6 | 3 | 0.94765 | 1.5272 | 0.0026316 | 0.2712 |
| miRNA target | TTCCGTT,MIR-191 | | 29 | 9 | 0.64417 | 1.2699 | 0.10408 | 0.19167 | ATACCTC,MIR-202 | | 166 | 56 | 0.60966 | 1.2719 | 0.002 | 0.19248 | ATGCTGG,MIR-338 | | 104 | 23 | 0.62396 | 1.2758 | 0.006 | 0.19375 | ATGTAGC,MIR-221,MIR-222 | | 133 | 45 | 0.62396 | 1.2766 | 0.004 | 0.19849 | AACATTC,MIR-409-3P | | 132 | 32 | 0.60846 | 1.2587 | 0.004008 | 0.19852 |
| Transcription factor target | GKCGCNNNNNNNTGAYG_UNKNOWN | | 52 | 17 | -0.52265 | -2.0365 | ≤0.001 | 0 | V$CEBP_01 | | 244 | 71 | 0.61884 | 1.2806 | ≤0.001 | 0.028315 | V$IRF1_01 | | 229 | 72 | 0.62167 | 1.2947 | ≤0.001 | 0.028349 | V$STAT5A_01 | | 231 | 77 | 0.62077 | 1.2809 | ≤0.001 | 0.028362 | V$TTF1_Q6 | | 243 | 83 | 0.62774 | 1.2951 | ≤0.001 | 0.028446 |
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