Research Article
Identification of Hub Genes Associated with Lung Adenocarcinoma Based on Bioinformatics Analysis
(a) The GO analysis results of upregulated differential genes |
| | Category | Term | Count | % | value | FDR |
| | GOTERM_CC_DIRECT | GO: 0005615~extracellular space | 39 | 14.82889734 | | 0.001099172 | | GOTERM_CC_DIRECT | GO: 0005578~proteinaceous extracellular matrix | 17 | 6.463878327 | | | | GOTERM_CC_DIRECT | GO: 0031012~extracellular matrix | 16 | 6.08365019 | | 0.001099172 | | GOTERM_MF_DIRECT | GO: 0046982~protein heterodimerization activity | 10 | 15.38461538 | | 0.002144305 | | GOTERM_CC_DIRECT | GO: 0005576~extracellular region | 38 | 14.4486692 | 0.001389295 | 0.034176669 | | GOTERM_BP_DIRECT | GO: 0060426~lung vasculature development | 3 | 1.140684411 | 0.002890084 | 0.264603216 | | GOTERM_BP_DIRECT | GO: 0007155~cell adhesion | 15 | 5.703422053 | 0.006047621 | 0.383326151 | | GOTERM_MF_DIRECT | GO: 0003677~DNA binding | 12 | 18.46153846 | 0.017676955 | 1 | | GOTERM_BP_DIRECT | GO: 0030198~extracellular matrix organization | 8 | 3.041825095 | 0.021602865 | 0.726561651 | | GOTERM_CC_DIRECT | GO: 0005581~collagen trimer | 5 | 1.901140684 | 0.038323481 | 0.336699153 | | GOTERM_BP_DIRECT | GO: 0001501~skeletal system development | 6 | 2.281368821 | 0.045594478 | 0.963329484 | | GOTERM_MF_DIRECT | GO: 0004252~serine-type endopeptidase activity | 4 | 6.153846154 | 0.050324984 | 1 | | GOTERM_MF_DIRECT | GO: 0004222~metalloendopeptidase activity | 3 | 4.615384615 | 0.052417683 | 1 | | GOTERM_MF_DIRECT | GO: 0019838~growth factor binding | 3 | 1.140684411 | 0.053114668 | 1 | | GOTERM_BP_DIRECT | GO: 0048845~venous blood vessel morphogenesis | 2 | 0.760456274 | 0.082095344 | 0.9933695 |
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(b) The GO analysis results of downregulated differential genes |
| | Category | Term | Count | % | value | FDR |
| | GOTERM_BP_DIRECT | GO: 0007160~cell-matrix adhesion | 8 | 3.041825095 | | 0.102142936 | | GOTERM_CC_DIRECT | GO: 0031982~vesicle | 8 | 3.041825095 | 0.001990645 | 0.044518052 | | GOTERM_BP_DIRECT | GO: 0045944~positive regulation of transcription from RNA polymerase II promoter | 26 | 9.885931559 | 0.003278681 | 0.284382424 | | GOTERM_MF_DIRECT | GO: 0004860~protein kinase inhibitor activity | 5 | 1.901140684 | 0.005702224 | 0.547413482 | | GOTERM_CC_DIRECT | GO: 0005764~lysosome | 9 | 3.422053232 | 0.013045455 | 0.168904314 | | GOTERM_BP_DIRECT | GO: 0001525~angiogenesis | 9 | 3.422053232 | 0.01406595 | 0.56315124 | | GOTERM_MF_DIRECT | GO: 0005178~integrin binding | 6 | 2.281368821 | 0.015197451 | 0.669135708 | | GOTERM_CC_DIRECT | GO: 0005667~transcription factor complex | 8 | 3.041825095 | 0.017573444 | 0.216153357 | | GOTERM_MF_DIRECT | GO: 0044325~ion channel binding | 6 | 2.281368821 | 0.020239455 | 0.747302944 | | GOTERM_CC_DIRECT | GO: 0005911~cell-cell junction | 7 | 2.661596958 | 0.031802418 | 0.320786082 | | GOTERM_CC_DIRECT | GO: 0005856~cytoskeleton | 11 | 4.182509506 | 0.033419216 | 0.320786082 | | GOTERM_MF_DIRECT | GO: 0008134~transcription factor binding | 9 | 3.422053232 | 0.04387505 | 1 | | GOTERM_BP_DIRECT | GO: 0007399~nervous system development | 9 | 3.422053232 | 0.05231756 | 0.9933695 | | GOTERM_BP_DIRECT | GO: 0071356~cellular response to tumor necrosis factor | 5 | 1.90114068441064 | 0.071273931 | 0.993369499698613 | | GOTERM_MF_DIRECT | GO: 0043014~alpha-tubulin binding | 3 | 1.140684411 | 0.056693325 | 1 |
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