Metabolic Analysis of Potential Key Genes Associated with Systemic Lupus Erythematosus Using Liquid Chromatography-Mass Spectrometry

Table 1

The top 10 upregulated and 10 downregulated proteins in SLE are listed.

Gene name	Abundances SLE1	Abundances SLE2	Abundances SLE3	Abundances CON1	Abundances CON2	Abundances CON3	Regulation	SLE/CON	value
ORM1	192.3	163.1	135.6	34	37.6	37.5	Up	4.500	0.001
ORM2	176	147.8	146.7	41.9	45.8	41.8	Up	3.633	0.000
APOC3	167.6	141.7	119.2	56.9	58.7	55.9	Up	2.499	0.004
APOC4	134.8	99.4	179.2	59.1	64.5	63	Up	2.215	0.031
IGLV3-10	153.3	94.1	142.4	78.6	64	67.5	Up	1.855	0.033
MMP3	124.4	143.1	111.2	80.6	72.1	68.6	Up	1.711	0.006
SAA4	117.4	117.5	134	77.8	81	72.3	Up	1.596	0.002
IGLV3-27	131.4	112.7	115.5	74.9	68	97.5	Up	1.496	0.020
VWF	133.5	116.2	109	78	83.1	80.3	Up	1.486	0.006
PIGR	105.2	111.1	140.3	81.5	88.1	73.8	Up	1.465	0.031
LUM	73.9	89.6	79.6	107.1	121.4	128.6	Down	0.681	0.008
PI16	67.3	98.5	76.8	106.2	122.2	129	Down	0.679	0.029
AHSP	82.7	69	89.6	136.6	95.5	126.6	Down	0.673	0.047
IGF2	81.5	77.4	79.2	117.4	126.4	118.1	Down	0.658	0.000
FAP	83.3	70.3	79.7	116.7	127.1	123	Down	0.636	0.001
THBS4	74	74	79.7	115.6	126.1	130.5	Down	0.612	0.001
APEH	77.3	71.3	78.4	118.8	99.6	154.6	Down	0.609	0.040
CBLN4	71.8	78.9	75.7	98.8	140	134.9	Down	0.606	0.020
KIT	71.2	77.6	77.4	135.8	123.2	114.8	Down	0.605	0.002
OMD	82.4	69.6	70.1	105.3	119.5	153.1	Down	0.588	0.025