[Retracted] miR-18a-5p Facilitates Malignant Progression of Head and Neck Squamous Cell Carcinoma Cells via Modulating SORBS2

Figure 3

miR-18a-5p inhibits SORBS2 level in HNSCC cells. (a) Volcano plot of DE-mRNAs in normal and tumor groups of HNSCC in TCGA database. Red: logFC > 2 and padj < 0.05, upregulated mRNAs; green: logFC < 2 and padj < 0.05, downregulated mRNAs. (b) Venn diagram of likely target genes from miR-18a-5p and DE-mRNAs. vn-genes represent mRNAs that are differentially downregulated in HNSCC. (c) Correlation analysis of miR-18a-5p and target gene mRNAs. (d) Box plot of SORBS2 level in normal and tumor groups. (e) Schematic diagram of sequence binding of SORBS2-WT, SORBS2-MUT, and miR-18a-5p. (f) Dual-luciferase assay was launched to examine luciferase viability in different groups of HNSCC cell SCC-15. (g) SORBS2 mRNA expression in HNSCC cell SCC-15 was detected in qRT-PCR assay. (h) SORBS2 protein expression in HNSCC cells was evaluated in Western blot assay. represents .

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