Research Article
Integration of Multiple-Omics Data to Analyze the Population-Specific Differences for Coronary Artery Disease
Table 2
Genes that are causally associated with the risk of CAD.
| | Population | eQTL | Probe ID | CHR | Gene | Top SNP | p_GWAS | p_eQTL | b_SMR | p_SMR | p_HEIDI |
| | European | Artery coronary | ENSG00000144426.14 | 2 | NBEAL1 | rs2351524 | 0.4860822 | 2.77-09 | -0.314 | 8.42-06 | 0.533 | | East Asian | Artery aorta | ENSG00000272750.1 | 1 | RP11-378J18.8 | rs2291832 | 3.672-10 | 2.01-30 | -0.161 | 3.79-08 | 4.54-04 | | ENSG00000112137.12 | 6 | PHACTR1 | rs9349379 | 1.177-13 | 1.68-11 | -0.616 | 6.12-07 | 1.72-07 | | ENSG00000272379.1 | 6 | RP1-257A7.5 | rs9349379 | 1.177-13 | 4.01-10 | -0.576 | 1.72-06 | NA | | ENSG00000180263.9 | 12 | FGD6 | rs7954260 | 8.589-08 | 1.49-17 | 0.228 | 5.70-06 | 0.198 | | ENSG00000136378.10 | 15 | ADAMTS7 | rs7173743 | 2.741-08 | 4.94-13 | -0.329314 | 1.06-05 | 0.00590 | | Artery coronary | ENSG00000272750.1 | 1 | RP11-378J18.8 | rs17163358 | 1.854-09 | 2.78-10 | -0.202 | 1.32-05 | 0.00121 | | Blood | ENSG00000089169.10 | 12 | RPH3A | rs7979186 | 5.75-09 | 7.75-55 | -0.150 | 4.95-08 | 6.11-04 | | Heart atrial appendage | ENSG00000272750.1 | 1 | RP11-378J18.8 | rs61824331 | 3.534-08 | 3.07-20 | -0.172 | 2.20-06 | 0.0129 | | ENSG00000175164.9 | 9 | ABO | rs643434 | 5.315-08 | 5.00-22 | 0.170 | 2.20-06 | 2.07-05 | | Heart left ventricle | ENSG00000272750.1 | 1 | RP11-378J18.8 | rs2291832 | 3.672-10 | 1.41-23 | -0.155 | 1.08-07 | 3.71-04 | | ENSG00000175164.9 | 9 | ABO | rs657152 | 6.34-09 | 6.84-20 | 0.214 | 9.14-07 | 1.053-05 |
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